Fig. 2. Effect of ITH12674 on retinal responsiveness. (A, B) Dark-adapted intensity responses to single- (A) and double-flash (B) ERG stimuli at 0 log cd s/m² from a normal mouse (C57BL/6J), a non-treated dystrophic mouse (rd10) and ITH12674-treated rd10 mice (rd10 + ITH12674) at P30. (C) Luminance-response curves of rd10 mice non-treated (n=7, circles) and treated with ITH12674 (inverted triangles) at a dose of 1 mg/kg (n=4, upper graphs) or 10 mg/Kg (n=15, lower graphs) from P16 to P30. Each graph includes measurements from both mixed (grey symbols) and cone-driven (white symbols) responses. Data are mean values ± SEM. *P<0.01, **P<0.005, ***P<0.001.